【印刷可能】 C[uC T[ i» ¨··ß 316205
Positive And Negative Effects Of The Major Mammalian Messenger Ribonucleoprotein P50 On Binding Of 40 S Ribosomal Subunits To The Initiation Codon Of B Globin Mrna Journal Of Biological Chemistry Purified AID catalyses the deamination of C to U on singlestranded (ss)DNA Here, we show in vitro that AIDcatalysed C deaminations occur preferentially on 5' WRC sequences in accord with SHM spectra observed in vivo Although about 98% of DNA clones suffer no mutations, most of the remaining mutated clones have 1070 C to T transitions per8 = S on a SS 14 3 = B M (S H T R) 15 4 = Q in a G 16 24 = H in a D 17 1 = W on a U 18 57 = H V 19 5 = D in a Z C 11 = P on a F B T 21 1000 = W that a P is W C[uC T[ i» ¨··ß